Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase

Mithun Raje, Niyada Hin, Bridget Duvall, Dana V. Ferraris, James F. Berry, Ajit G. Thomas, Jesse Alt, Camilo Rojas, Barbara Slusher, Takashi Tsukamoto

Research output: Contribution to journalArticle

Abstract

A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit d-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

Original languageEnglish (US)
Pages (from-to)3910-3913
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number13
DOIs
StatePublished - Jul 1 2013

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Oxidoreductases
Binding Sites
Derivatives
Amino Acids
Molecular Probes
kojic acid

Keywords

  • d-Amino acid oxidase
  • Flavoenzyme
  • Kojic acid
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase. / Raje, Mithun; Hin, Niyada; Duvall, Bridget; Ferraris, Dana V.; Berry, James F.; Thomas, Ajit G.; Alt, Jesse; Rojas, Camilo; Slusher, Barbara; Tsukamoto, Takashi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 23, No. 13, 01.07.2013, p. 3910-3913.

Research output: Contribution to journalArticle

Raje, Mithun ; Hin, Niyada ; Duvall, Bridget ; Ferraris, Dana V. ; Berry, James F. ; Thomas, Ajit G. ; Alt, Jesse ; Rojas, Camilo ; Slusher, Barbara ; Tsukamoto, Takashi. / Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase. In: Bioorganic and Medicinal Chemistry Letters. 2013 ; Vol. 23, No. 13. pp. 3910-3913.
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