Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase

Mithun Raje, Niyada Hin, Bridget Duvall, Dana V. Ferraris, James F. Berry, Ajit G. Thomas, Jesse Alt, Camilo Rojas, Barbara S. Slusher, Takashi Tsukamoto

Research output: Contribution to journalArticle

Abstract

A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit d-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

Original languageEnglish (US)
Pages (from-to)3910-3913
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number13
DOIs
StatePublished - Jul 1 2013

Keywords

  • Flavoenzyme
  • Kojic acid
  • Schizophrenia
  • d-Amino acid oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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