Synthesis of huperzine A and its analogues and their anticholinesterase activity

Alan P. Kozikowski, Yan Xia, E. Rajarathnam Reddy, Werner Tückmantel, Israel Hanin, X. C. Tang

Research output: Contribution to journalArticle

Abstract

Huperzine A is a new alkaloid isolated from the club moss Huperzia serrata (Thunb.) Trev., a Chinese folk medicine. This alkaloid exhibits potent activity as an inhibitor of acetylcholinesterase. Consequently, the compound is presently being investigated in China for the treatment of individuals suffering from various forms of memory impairment including Alzheimer's dementia. Details of the total synthesis of (±)-huperzine A are described as well as the preparation of a variety of huperzine analogues including its presumed pharmacophore. The extent of these new compounds to inhibit acetylcholinesterase is presented along with a discussion of the effects of the structural changes on biological activity.

Original languageEnglish (US)
Pages (from-to)4636-4645
Number of pages10
JournalJournal of Organic Chemistry
Volume56
Issue number15
StatePublished - 1991
Externally publishedYes

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Cholinesterase Inhibitors
Alkaloids
Acetylcholinesterase
Bioactivity
Medicine
Data storage equipment
huperzine A

ASJC Scopus subject areas

  • Organic Chemistry

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Kozikowski, A. P., Xia, Y., Reddy, E. R., Tückmantel, W., Hanin, I., & Tang, X. C. (1991). Synthesis of huperzine A and its analogues and their anticholinesterase activity. Journal of Organic Chemistry, 56(15), 4636-4645.

Synthesis of huperzine A and its analogues and their anticholinesterase activity. / Kozikowski, Alan P.; Xia, Yan; Reddy, E. Rajarathnam; Tückmantel, Werner; Hanin, Israel; Tang, X. C.

In: Journal of Organic Chemistry, Vol. 56, No. 15, 1991, p. 4636-4645.

Research output: Contribution to journalArticle

Kozikowski, AP, Xia, Y, Reddy, ER, Tückmantel, W, Hanin, I & Tang, XC 1991, 'Synthesis of huperzine A and its analogues and their anticholinesterase activity', Journal of Organic Chemistry, vol. 56, no. 15, pp. 4636-4645.
Kozikowski AP, Xia Y, Reddy ER, Tückmantel W, Hanin I, Tang XC. Synthesis of huperzine A and its analogues and their anticholinesterase activity. Journal of Organic Chemistry. 1991;56(15):4636-4645.
Kozikowski, Alan P. ; Xia, Yan ; Reddy, E. Rajarathnam ; Tückmantel, Werner ; Hanin, Israel ; Tang, X. C. / Synthesis of huperzine A and its analogues and their anticholinesterase activity. In: Journal of Organic Chemistry. 1991 ; Vol. 56, No. 15. pp. 4636-4645.
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