Synthesis of fluorine-containing isosteres of sphingosine as inactivators of protein kinase C

Alan P. Kozikowski, Jiang Ping Wu

Research output: Contribution to journalArticle

Abstract

Syntheses of isosteres of D-sphingosine in which either the primary or the secondary hydroxyl group of the parent compound has been replaced by a fluorine substituent are described.

Original languageEnglish (US)
Pages (from-to)4309-4312
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number30
DOIs
StatePublished - 1990
Externally publishedYes

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Sphingosine
Fluorine
Hydroxyl Radical
Protein Kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of fluorine-containing isosteres of sphingosine as inactivators of protein kinase C. / Kozikowski, Alan P.; Wu, Jiang Ping.

In: Tetrahedron Letters, Vol. 31, No. 30, 1990, p. 4309-4312.

Research output: Contribution to journalArticle

Kozikowski, Alan P. ; Wu, Jiang Ping. / Synthesis of fluorine-containing isosteres of sphingosine as inactivators of protein kinase C. In: Tetrahedron Letters. 1990 ; Vol. 31, No. 30. pp. 4309-4312.
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