Synthesis of diporphyrins via palladium-catalyzed C-O bond formation: Effective access to chiral diporphyrins

Guang Yao Gao, Joshua V. Ruppel, Kimberly B. Fields, E. Xu, Ying Chen, X. Peter Zhang

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Diporphyrins can be efficiently synthesized from bromoporphyrin precursors via palladium-catalyzed C-O bond formation. The synthetic methodology is general and can be applied to various diols, forming a series of homo-diporphyrins containing different types of spacers in high to excellent yields. Chiral diporphyrins can be readily constructed through the use of optically active diols. A similar strategy allows access to hetero-diporphyrins and triporphyrins, including free-base and metalloporphyrin hetero dimers.

Original languageEnglish (US)
Pages (from-to)4855-4858
Number of pages4
JournalJournal of Organic Chemistry
Volume73
Issue number13
DOIs
StatePublished - Jul 4 2008

ASJC Scopus subject areas

  • Organic Chemistry

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