Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

Alan P. Kozikowski, Garth Powis, Alfred Gallegos, Werner Tückmantel

Research output: Contribution to journalArticle

Abstract

The title compounds were synthesized in optically pure form from L-quebrachitol via the known 3-homologated inositol derivative 1; also prepared were D-3-deoxy-3-methylene-, -3-(hydroxymethyl)-, and -3-(iodomethyl)-myo-inositol. None of these compounds significantly inhibited the growth of wild type and v-sis-transformed NIH 3T3 cells at millimolar concentration.

Original languageEnglish (US)
Pages (from-to)1323-1326
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Inositol
Phosphatidylinositol 3-Kinases
Esters
L Forms
NIH 3T3 Cells
Derivatives
Growth
quebrachitol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway. / Kozikowski, Alan P.; Powis, Garth; Gallegos, Alfred; Tückmantel, Werner.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 6, 1993, p. 1323-1326.

Research output: Contribution to journalArticle

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