Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Jason A. Smulik, Steven T. Diver, Fan Pan, Jun O. Liu

Research output: Contribution to journalArticlepeer-review

Abstract

(Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

Original languageEnglish (US)
Pages (from-to)2051-2054
Number of pages4
JournalOrganic Letters
Volume4
Issue number12
DOIs
StatePublished - Jun 13 2002

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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