Synthesis of cyclic sphingosine 1,3-phosphate (cSPP) through a photolytic reaction

Lixin Qiao, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of cyclic sphingosine 1,3-phosphate through photolytic methodology is described starting from D-erythro-sphingosine. A bifunctional phosphorylating reagent, 2-cyanoethyl N,N-diisopropylchlorophosphoramidite, is used to introduce the cyclic 1,3-phosphate moiety. This procedure generates cSPP in four steps and in 36% overall yield.

Original languageEnglish (US)
Pages (from-to)8959-8962
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number49
DOIs
StatePublished - Dec 3 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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