Synthesis of carbon‐11 labeled methylcarbamates from [11C]‐methylchloroformate

Hayden T. Ravert, William B. Mathews, John L. Musachio, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review

Abstract

[11C]‐Methylchloroformate, a novel [11C]‐acylating agent, was generated in situ from [11C]‐methanol and phosgene. To explore the utility of [11C]‐methylchloroformate, this agent was reacted with several amines to yield their corresponding [11C]‐labeled methylcarbamates. The average synthesis (including purification and formulation) required approximately 23 minutes from end of bombardment. The average specific activity was calculated to be approx. 607 mCi/μmole at end of synthesis with an average radiochemical yield of 6%, decay corrected to starting [11C]‐methanol. Preliminary results reveal that [11C]‐methylchloroformate is a useful general reagent for the preparation of [11C]‐methyl carbamates of both primary and secondary amines.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume36
Issue number4
DOIs
StatePublished - Apr 1995

Keywords

  • Methylcarbamate
  • antihistamine
  • carbon‐11
  • positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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