Synthesis of carbon-11 labeled diprenorphine

A radioligand for positron emission tomographic studies of opiate receptors

John R. Lever, Robert F Dannals, Alan A. Wilson, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

Selective alkylation of 3-(O-t-butyldimethylsilyl)-6-(O-desmethyl)-diprenorphine with [11C]-methyl iodide followed by desilylation affords [11C]-dipronorphine labeled at the 6-methoxy position in 10% yield with a specific activity of 1740 mCi/μmol at the end of a 30 minute synthesis.

Original languageEnglish (US)
Pages (from-to)4015-4018
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number35
DOIs
StatePublished - 1987

Fingerprint

Diprenorphine
Alkylation
Opioid Receptors
Positrons
Carbon
Electrons
methyl iodide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of carbon-11 labeled diprenorphine : A radioligand for positron emission tomographic studies of opiate receptors. / Lever, John R.; Dannals, Robert F; Wilson, Alan A.; Ravert, Hayden T.; Wagner, Henry N.

In: Tetrahedron Letters, Vol. 28, No. 35, 1987, p. 4015-4018.

Research output: Contribution to journalArticle

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