Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.
|Original language||English (US)|
|Number of pages||3|
|Journal||International Journal of Radiation Applications and Instrumentation. Part|
|State||Published - 1990|
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