Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram

Robert F. Dannals; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner

doi:10.1016/0883-2889(90)90036-G

Synthesis of a selective serotonin uptake inhibitor: [¹¹C]citalopram

Robert F. Dannals, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with ¹¹C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [¹¹C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.

Original language	English (US)
Pages (from-to)	541-543
Number of pages	3
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/0883-2889(90)90036-G
State	Published - 1990

ASJC Scopus subject areas

Radiation
General Engineering

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10.1016/0883-2889(90)90036-G

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title = "Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram",

abstract = "Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.",

author = "Dannals, {Robert F.} and Ravert, {Hayden T.} and Wilson, {Alan A.} and Wagner, {Henry N.}",

note = "Funding Information: This work wass upportedin part by Grant Nos NS-15080 and CA-32845 from the U.S. Public Health Service.",

year = "1990",

doi = "10.1016/0883-2889(90)90036-G",

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T1 - Synthesis of a selective serotonin uptake inhibitor

T2 - [11C]citalopram

AU - Dannals, Robert F.

AU - Ravert, Hayden T.

AU - Wilson, Alan A.

AU - Wagner, Henry N.

N1 - Funding Information: This work wass upportedin part by Grant Nos NS-15080 and CA-32845 from the U.S. Public Health Service.

PY - 1990

Y1 - 1990

N2 - Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.

AB - Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.

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JF - International Journal of Radiation Applications and Instrumentation. Part

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Synthesis of a selective serotonin uptake inhibitor: [¹¹C]citalopram

Abstract

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