Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram

Robert F. Dannals, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

Citalopram (Fig. 1), a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume41
Issue number6
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

Fingerprint

Dive into the research topics of 'Synthesis of a selective serotonin uptake inhibitor: [<sup>11</sup>C]citalopram'. Together they form a unique fingerprint.

Cite this