Abstract
The radiochemical synthesis of 2-[18F]fluoro-3-(2(S)- azetidinylmethoxy)pyridine (2-[18F]A-85380, [18F]1) was accomplished by Kryptofix® 222 assisted nucleophilic no-carrier-added [18F]fluorination of 2-iodo-3-((1-tert-butoxycarbonyl-2(S)-azetidinyl)methoxy)pyridine, 2 followed by acidic deprotection. The average radiochemical yield was 10% and the average specific radioactivity was 1050 mCi/μmol, calculated at end-of- synthesis (EOS).
Original language | English (US) |
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Pages (from-to) | 309-318 |
Number of pages | 10 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 41 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1998 |
Keywords
- A-85380
- Acetylcholine
- F
- Fluorination
- Halogen-exchange
- Nicotinic receptors
- Positron emission tomography
- Radiotracer
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry