Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane ([11C]CFT or [11C]WIN‐35,428)

Robert F. Dannals, John L. Neumeyer, Richard A. Milius, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume33
Issue number2
DOIs
StatePublished - Feb 1993

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Keywords

  • carbon‐11
  • dopamine uptake sites
  • positron emission tomography
  • radiotracer
  • synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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