Synthesis of a mGluR5 antagonist using [11C]cOpper(I) cyanide

William B. Mathews, James A. Monn, Hayden T. Ravert, Daniel P. Holt, Darryle D. Schoepp, Robert F. Dannals

Research output: Contribution to journalArticlepeer-review


5-(2-Phenylethynyl)pyridine-3-[11C]carbonitrile ([ 11C]LY2232645), a metabotropic glutamate 5 receptor (mGluR5) antagonist, was synthesized by a no-carrier-added nucleophilic halogen displacement with [11C]copper(I) cyanide. The average radiochemical yield was 2.5%, and the average specific activity was 1365 mCi/μmol at end-of-synthesis. The total time of synthesis, purification, and formulation was 26 min.

Original languageEnglish (US)
Pages (from-to)829-834
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number9
StatePublished - Aug 1 2006


  • C
  • Copper cyanide
  • Glutamate
  • PET
  • mGluR5

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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