Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Gopishetti Bhaskar, Anchoori Ravi Kumar, Errabelli Ramu, Batchu Venkateswara Rao

Research output: Contribution to journalArticlepeer-review

Abstract

A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

Original languageEnglish (US)
Article numberZ11008SS
Pages (from-to)3061-3064
Number of pages4
JournalSynthesis
Issue number19
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Keywords

  • HIV-AIDS
  • Peptidomimetic aspartyl protease inhibitors
  • Regioselective epoxide opening

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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