Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Gopishetti Bhaskar, Ravi Anchoori, Errabelli Ramu, Batchu Venkateswara Rao

Research output: Contribution to journalArticle

Abstract

A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

Original languageEnglish (US)
Article numberZ11008SS
Pages (from-to)3061-3064
Number of pages4
JournalSynthesis
Issue number19
DOIs
Publication statusPublished - Oct 1 2008
Externally publishedYes

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Keywords

  • HIV-AIDS
  • Peptidomimetic aspartyl protease inhibitors
  • Regioselective epoxide opening

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

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