Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Gopishetti Bhaskar; Anchoori Ravi Kumar; Errabelli Ramu; Batchu Venkateswara Rao

doi:10.1055/s-2008-1067252

Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Gopishetti Bhaskar, Anchoori Ravi Kumar, Errabelli Ramu, Batchu Venkateswara Rao

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

Original language	English (US)
Article number	Z11008SS
Pages (from-to)	3061-3064
Number of pages	4
Journal	Synthesis
Issue number	19
DOIs	https://doi.org/10.1055/s-2008-1067252
State	Published - Oct 1 2008
Externally published	Yes

Keywords

HIV-AIDS
Peptidomimetic aspartyl protease inhibitors
Regioselective epoxide opening

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-2008-1067252

Cite this

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title = "Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer",

abstract = "A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.",

keywords = "HIV-AIDS, Peptidomimetic aspartyl protease inhibitors, Regioselective epoxide opening",

author = "Gopishetti Bhaskar and Kumar, {Anchoori Ravi} and Errabelli Ramu and Rao, {Batchu Venkateswara}",

year = "2008",

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AU - Bhaskar, Gopishetti

AU - Kumar, Anchoori Ravi

AU - Ramu, Errabelli

AU - Rao, Batchu Venkateswara

PY - 2008/10/1

Y1 - 2008/10/1

N2 - A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

AB - A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

KW - HIV-AIDS

KW - Peptidomimetic aspartyl protease inhibitors

KW - Regioselective epoxide opening

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Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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