Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Gopishetti Bhaskar, Ravi Anchoori, Errabelli Ramu, Batchu Venkateswara Rao

Research output: Contribution to journalArticle

Abstract

A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

Original languageEnglish (US)
Article numberZ11008SS
Pages (from-to)3061-3064
Number of pages4
JournalSynthesis
Issue number19
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Fingerprint

Lopinavir
HIV Protease Inhibitors
Ritonavir
Dipeptides
hydroxyethylene
Peptide Hydrolases

Keywords

  • HIV-AIDS
  • Peptidomimetic aspartyl protease inhibitors
  • Regioselective epoxide opening

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

Cite this

Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer. / Bhaskar, Gopishetti; Anchoori, Ravi; Ramu, Errabelli; Rao, Batchu Venkateswara.

In: Synthesis, No. 19, Z11008SS, 01.10.2008, p. 3061-3064.

Research output: Contribution to journalArticle

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