Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

V. Rajendran; Suo Bao Rong; Ashima Saxena; Bhupendra P. Doctor; Alan P. Kozikowski

doi:10.1016/S0040-4039(01)01008-5

Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

V. Rajendran, Suo Bao Rong, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.

Original language	English (US)
Pages (from-to)	5359-5361
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	32
DOIs	https://doi.org/10.1016/S0040-4039(01)01008-5
State	Published - Aug 6 2001

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01008-5

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title = "Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B",

abstract = "The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.",

author = "V. Rajendran and Rong, {Suo Bao} and Ashima Saxena and Doctor, {Bhupendra P.} and Kozikowski, {Alan P.}",

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AU - Rajendran, V.

AU - Rong, Suo Bao

AU - Saxena, Ashima

AU - Doctor, Bhupendra P.

AU - Kozikowski, Alan P.

PY - 2001/8/6

Y1 - 2001/8/6

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AB - The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.

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Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

Abstract

ASJC Scopus subject areas

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