Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

V. Rajendran, Suo Bao Rong, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.

Original languageEnglish (US)
Pages (from-to)5359-5361
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number32
DOIs
StatePublished - Aug 6 2001

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Rajendran, V., Rong, S. B., Saxena, A., Doctor, B. P., & Kozikowski, A. P. (2001). Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B. Tetrahedron Letters, 42(32), 5359-5361. https://doi.org/10.1016/S0040-4039(01)01008-5