Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes

Dawei Ma, Guozhi Tang, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

(Matrix Presented) Condensation of L-valine benzyl ester toluenesulfonic acid salt with a substituted cyclohexadione followed by aromatization with the assistance of NBS provides an N-aryl L-valine benzyl ester. This intermediate is converted into 7-substituted benzolactam-V8s using an asymmetric Strecker reaction as the key step. The target molecules show a different pattern of isozyme selectivity relative to the 8-substituted benzolactam-V8s.

Original languageEnglish (US)
Pages (from-to)2377-2380
Number of pages4
JournalOrganic Letters
Volume4
Issue number14
DOIs
StatePublished - Jul 11 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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