Abstract
2-[18F]fluoroadenosine (2-[18F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[18F]FAD were 5%, 22-30 mCi/μmol and 99%, and 0.5%, 1200-1700 mCi/μmol and 99%, respectively.
Original language | English (US) |
---|---|
Pages (from-to) | 811-815 |
Number of pages | 5 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 49 |
Issue number | 9 |
DOIs | |
State | Published - Aug 2006 |
Keywords
- 2-[F] fluoroadenosine
- Adenylate metabolism
- Cancer
- F
- Positron emission tomography
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry