Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

Andrew G. Horti, Hayden T. Ravert, William B. Mathews, Edward H. Abraham, Richard L. Wahl, Robert F. Dannals

Research output: Contribution to journalArticle

Abstract

2-[18F]fluoroadenosine (2-[18F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[18F]FAD were 5%, 22-30 mCi/μmol and 99%, and 0.5%, 1200-1700 mCi/μmol and 99%, respectively.

Original languageEnglish (US)
Pages (from-to)811-815
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume49
Issue number9
DOIs
StatePublished - Aug 1 2006

Keywords

  • 2-[F] fluoroadenosine
  • Adenylate metabolism
  • Cancer
  • F
  • Positron emission tomography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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