Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

S. Sakamuri, I. J. Enyedy, A. P. Kozikowski, S. Wang

Research output: Contribution to journalArticle

Abstract

The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)9949-9952
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number51
StatePublished - Dec 16 2000
Externally publishedYes

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Quinuclidines
Dopamine Plasma Membrane Transport Proteins
Enantiomers
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Sakamuri, S., Enyedy, I. J., Kozikowski, A. P., & Wang, S. (2000). Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. Tetrahedron Letters, 41(51), 9949-9952.

Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. / Sakamuri, S.; Enyedy, I. J.; Kozikowski, A. P.; Wang, S.

In: Tetrahedron Letters, Vol. 41, No. 51, 16.12.2000, p. 9949-9952.

Research output: Contribution to journalArticle

Sakamuri, S, Enyedy, IJ, Kozikowski, AP & Wang, S 2000, 'Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors', Tetrahedron Letters, vol. 41, no. 51, pp. 9949-9952.
Sakamuri S, Enyedy IJ, Kozikowski AP, Wang S. Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. Tetrahedron Letters. 2000 Dec 16;41(51):9949-9952.
Sakamuri, S. ; Enyedy, I. J. ; Kozikowski, A. P. ; Wang, S. / Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 51. pp. 9949-9952.
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