TY - JOUR
T1 - Synthesis of (±)-10,10-dimethylhuperzine A - A huperzine analogue possessing a slower enzyme off-rate
AU - Kozikowski, Alan P.
AU - Ding, Qingjie
AU - Saxena, Ashima
AU - Doctor, Bhupendra P.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - The synthesis of (±)-10,10-dimethylhuperzine A is reported together with its kinetic (kon and koff) and dissociation constants for the inhibition of fetal bovine serum acetylcholinesterase. While somewhat more potent than (±)-huperzine A, the dimethyl analogue shows a slower off-rate from AChE, a result that may be of potential therapeutic value.
AB - The synthesis of (±)-10,10-dimethylhuperzine A is reported together with its kinetic (kon and koff) and dissociation constants for the inhibition of fetal bovine serum acetylcholinesterase. While somewhat more potent than (±)-huperzine A, the dimethyl analogue shows a slower off-rate from AChE, a result that may be of potential therapeutic value.
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U2 - 10.1016/0960-894X(96)00012-1
DO - 10.1016/0960-894X(96)00012-1
M3 - Article
AN - SCOPUS:0030041404
VL - 6
SP - 259
EP - 262
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -