Synthesis, molecular modeling, and biology of the 1-benzyl derivative of APDC - an apparent mGluR6 selective ligand

Werner Tückmantel, Alan P. Kozikowski, Shaomeng Wang, Sergey Pshenichkin, Jarda T. Wroblewski

Research output: Contribution to journalArticle

Abstract

The synthesis of the 1-benzyl derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-benzyl-APDC) starting from cis-4-hydroxy-D-proline is disclosed together with a study of the activity of this compound at metabotropic glutamate receptors (mGluRs). The compound was found to display good mGluR6 selectivity, and may thus be a useful pharmacological research tool.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number5
DOIs
StatePublished - Mar 4 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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