Synthesis and protein kinase C binding activity of benzolactam-V7

Dawei Ma, Guoqiang Wang, Shaomeng Wang, Alan P. Kozikowski, Nancy E. Lewin, Peter M. Blumberg

Research output: Contribution to journalArticle

Abstract

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number10
DOIs
StatePublished - May 17 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Ma, D., Wang, G., Wang, S., Kozikowski, A. P., Lewin, N. E., & Blumberg, P. M. (1999). Synthesis and protein kinase C binding activity of benzolactam-V7. Bioorganic and Medicinal Chemistry Letters, 9(10), 1371-1374. https://doi.org/10.1016/S0960-894X(99)00207-3