Synthesis and protein kinase C binding activity of benzolactam-V7

Dawei Ma; Guoqiang Wang; Shaomeng Wang; Alan P. Kozikowski; Nancy E. Lewin; Peter M. Blumberg

doi:10.1016/S0960-894X(99)00207-3

Synthesis and protein kinase C binding activity of benzolactam-V7

Dawei Ma, Guoqiang Wang, Shaomeng Wang, Alan P. Kozikowski, Nancy E. Lewin, Peter M. Blumberg

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.

Original language	English (US)
Pages (from-to)	1371-1374
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(99)00207-3
State	Published - May 17 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00207-3

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title = "Synthesis and protein kinase C binding activity of benzolactam-V7",

abstract = "Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.",

author = "Dawei Ma and Guoqiang Wang and Shaomeng Wang and Kozikowski, {Alan P.} and Lewin, {Nancy E.} and Blumberg, {Peter M.}",

note = "Funding Information: Acknowledgments: The authors are grateful to the Chinese Academy of Sciences and National Natural Science Foundation of China (Project 29725205) for their financial support.",

year = "1999",

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doi = "10.1016/S0960-894X(99)00207-3",

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T1 - Synthesis and protein kinase C binding activity of benzolactam-V7

AU - Ma, Dawei

AU - Wang, Guoqiang

AU - Wang, Shaomeng

AU - Kozikowski, Alan P.

AU - Lewin, Nancy E.

AU - Blumberg, Peter M.

N1 - Funding Information: Acknowledgments: The authors are grateful to the Chinese Academy of Sciences and National Natural Science Foundation of China (Project 29725205) for their financial support.

PY - 1999/5/17

Y1 - 1999/5/17

N2 - Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.

AB - Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.

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DO - 10.1016/S0960-894X(99)00207-3

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis and protein kinase C binding activity of benzolactam-V7

Abstract

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