Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives

Ling Wei, Joseph P. Steiner, Gregory S. Hamilton, Yong Qian Wu

Research output: Contribution to journalArticle

Abstract

In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant analogues of cyclosporin A, modified at the various positions in the 'effector' domain, are equipotent nerve growth agents compared to cyclosporin A. Our results suggest that neurotrophic activity of cyclosporin A and its derivatives resides in the binding domain, and binding to cyclophilin and/or inhibiting rotamase activity may be a necessity for neurotrophic effects of cyclophilin ligands.

Original languageEnglish (US)
Pages (from-to)4549-4551
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number17
DOIs
StatePublished - Sep 6 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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