Synthesis and in vivo evaluation of novel PET radioligands for imaging the endothelin-A receptor

Medicine & Life Sciences

• N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,4-fluorobenzamide 100%
• N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide 79%
• Endothelin A Receptors 54%
• diphenyl 24%
• Heart 17%
• Papio 16%
• 4-fluorobenzamide 15%
• methyl iodide 11%
• Myocardium 11%
• High Pressure Liquid Chromatography 11%
• Amination 10%
• Lung 10%
• Alkylation 8%
• Aldehydes 7%
• Endothelins 7%
• Fluorides 7%
• Liver 6%
• Vasoconstriction 6%
• G-Protein-Coupled Receptors 6%
• Radioactivity 6%
• Tail 6%
• Intravenous Administration 6%
• Veins 5%
• Hormones 4%
• Cell Proliferation 4%
• Injections 3%
• Kidney 3%