Synthesis and in vitro antitumor activities of novel soladulcidine derivatives

Xiao Ming Zha, Fei Ran Zhang, Jia Qi Shan, Yan Ke Chen, Yi Hua Zhang, Jun Liu, Hong Bin Sun

Research output: Contribution to journalArticle

Abstract

Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalJournal of China Pharmaceutical University
Volume41
Issue number6
StatePublished - Dec 1 2010

Keywords

  • Antitumor activity
  • Soladulcidine derivatives
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Zha, X. M., Zhang, F. R., Shan, J. Q., Chen, Y. K., Zhang, Y. H., Liu, J., & Sun, H. B. (2010). Synthesis and in vitro antitumor activities of novel soladulcidine derivatives. Journal of China Pharmaceutical University, 41(6), 493-498.