Abstract
Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).
Original language | English (US) |
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Pages (from-to) | 493-498 |
Number of pages | 6 |
Journal | Journal of China Pharmaceutical University |
Volume | 41 |
Issue number | 6 |
State | Published - Dec 2010 |
Keywords
- Antitumor activity
- Soladulcidine derivatives
- Synthesis
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science