Synthesis and in vitro antitumor activities of novel soladulcidine derivatives

Xiao Ming Zha, Fei Ran Zhang, Jia Qi Shan, Yan Ke Chen, Yi Hua Zhang, Jun Liu, Hong Bin Sun

Research output: Contribution to journalArticle

Abstract

Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalJournal of China Pharmaceutical University
Volume41
Issue number6
StatePublished - Dec 2010

Fingerprint

Esterification
Solanum
Cell Line
Alkaloids
Inhibitory Concentration 50
Prostatic Neoplasms
spirosolan-3-ol
In Vitro Techniques

Keywords

  • Antitumor activity
  • Soladulcidine derivatives
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Zha, X. M., Zhang, F. R., Shan, J. Q., Chen, Y. K., Zhang, Y. H., Liu, J., & Sun, H. B. (2010). Synthesis and in vitro antitumor activities of novel soladulcidine derivatives. Journal of China Pharmaceutical University, 41(6), 493-498.

Synthesis and in vitro antitumor activities of novel soladulcidine derivatives. / Zha, Xiao Ming; Zhang, Fei Ran; Shan, Jia Qi; Chen, Yan Ke; Zhang, Yi Hua; Liu, Jun; Sun, Hong Bin.

In: Journal of China Pharmaceutical University, Vol. 41, No. 6, 12.2010, p. 493-498.

Research output: Contribution to journalArticle

Zha, XM, Zhang, FR, Shan, JQ, Chen, YK, Zhang, YH, Liu, J & Sun, HB 2010, 'Synthesis and in vitro antitumor activities of novel soladulcidine derivatives', Journal of China Pharmaceutical University, vol. 41, no. 6, pp. 493-498.
Zha, Xiao Ming ; Zhang, Fei Ran ; Shan, Jia Qi ; Chen, Yan Ke ; Zhang, Yi Hua ; Liu, Jun ; Sun, Hong Bin. / Synthesis and in vitro antitumor activities of novel soladulcidine derivatives. In: Journal of China Pharmaceutical University. 2010 ; Vol. 41, No. 6. pp. 493-498.
@article{ad1e303859004f83b017ad13561406f4,
title = "Synthesis and in vitro antitumor activities of novel soladulcidine derivatives",
abstract = "Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).",
keywords = "Antitumor activity, Soladulcidine derivatives, Synthesis",
author = "Zha, {Xiao Ming} and Zhang, {Fei Ran} and Shan, {Jia Qi} and Chen, {Yan Ke} and Zhang, {Yi Hua} and Jun Liu and Sun, {Hong Bin}",
year = "2010",
month = "12",
language = "English (US)",
volume = "41",
pages = "493--498",
journal = "Journal of China Pharmaceutical University",
issn = "1000-5048",
publisher = "China Pharmaceutical University",
number = "6",

}

TY - JOUR

T1 - Synthesis and in vitro antitumor activities of novel soladulcidine derivatives

AU - Zha, Xiao Ming

AU - Zhang, Fei Ran

AU - Shan, Jia Qi

AU - Chen, Yan Ke

AU - Zhang, Yi Hua

AU - Liu, Jun

AU - Sun, Hong Bin

PY - 2010/12

Y1 - 2010/12

N2 - Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).

AB - Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring or esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.8±0.9 μmol/L).

KW - Antitumor activity

KW - Soladulcidine derivatives

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=78651298449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651298449&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:78651298449

VL - 41

SP - 493

EP - 498

JO - Journal of China Pharmaceutical University

JF - Journal of China Pharmaceutical University

SN - 1000-5048

IS - 6

ER -