Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A

I. Z. Siemion, M. Cebrat, A. Pedyczak, M. Zimecki, Z. Wieczorek

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrated that a linear peptide Gly-Ile-Ile-Leu-Val-Pro-Pro-Phe, the analog of a cyclic nonapeptide c-(Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe) possesses a distinct immunosuppressive activity. We synthesized a series of eight other analogs of the linear peptide. The series consists of the nonapeptides protected on N- and/or C-terminus by acetyl-, succinyl-, and amido- functions and of Gly-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe elongated on N- and/or C-terminus by additional glycine residues. It was found that the protection of the terminal functional groups of the peptide slightly increases its immunosuppressor potency. At the same time the elongation of the peptide chain on both termini by additional glycine residues evokes a distinct increase of the immunosuppressive activity.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume41
Issue number5-6
StatePublished - 1993
Externally publishedYes

Keywords

  • cyclolinopeptide A
  • glycine containing analogs of cyclolinopeptide A
  • peptide immunosuppressors

ASJC Scopus subject areas

  • Immunology

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