Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF

J. Kipchirchir Bitok, Caren Freel Meyers

Research output: Contribution to journalArticlepeer-review

Abstract

Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, the E. coli IspF-MEP complex shows activities distinct from IspF, and bisphosphonates (BP) behave differently than their diphosphate (DP) counterparts. Bisphosphonate analogs activate and/or stabilize IspF, and only the closest structural substrate analog weakly inhibits the IspF-MEP complex.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalMedChemComm
Volume4
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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