Abstract
Combinations of an amidoalkylphosphocholine, 8, and AZT have been found to cause an apparent synergistic action in suppressing infectious HIV-1 replication. In addition, amidoalkyl, oxyalkyl, and thioalkyl ether lipids have been chemically linked to anti-HIV-1 nucleosides (AZT and DDI) through phosphate and phosphonate linkages. These conjugates have shown promising in vitro anti-HIV-1 activity. Also, the conjugates have a 5-10-fold reduction in cell cytotoxicity compared to AZT alone. The most active compound, an amidoalkyl ether lipid-AZT conjugate, 4A, was found to have a differential selectivity of 1793 in a syncytial plaque assay. In comparison, AZT alone has a value of 1281.
Original language | English (US) |
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Pages (from-to) | 1408-1414 |
Number of pages | 7 |
Journal | Journal of medicinal chemistry |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery