Abstract
The synthesis, scavenging activity, and cytoprotective profiles of histidyl-containing carnosine analogues bearing hydrazide or 1,2-diol moieties is reported. Some compounds have demonstrated higher aldehyde-sequestering efficiency than carnosine and were also efficient in protecting SH-SY5Y neuroblastoma cells and rat hippocampal neurons from 4-hydroxy-trans-2,3-nonenal (HNE)-mediated death. The cytoprotective efficacy of these compounds suggests their potential use as therapeutic agents for disorders that involve excessive membrane lipids peroxidation and HNE-mediated neuronal toxicity.
Original language | English (US) |
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Pages (from-to) | 6156-6161 |
Number of pages | 6 |
Journal | Journal of Medicinal Chemistry |
Volume | 48 |
Issue number | 19 |
DOIs | |
State | Published - Sep 22 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry