Synthesis and evaluation of neuroprotective α,β-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine

Andrea Guiotto, Andrea Calderan, Paolo Ruzza, Alessio Osler, Chiara Rubini, Dong Gyu Jo, Mark P. Mattson, Gianfranco Borin

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis, scavenging activity, and cytoprotective profiles of histidyl-containing carnosine analogues bearing hydrazide or 1,2-diol moieties is reported. Some compounds have demonstrated higher aldehyde-sequestering efficiency than carnosine and were also efficient in protecting SH-SY5Y neuroblastoma cells and rat hippocampal neurons from 4-hydroxy-trans-2,3-nonenal (HNE)-mediated death. The cytoprotective efficacy of these compounds suggests their potential use as therapeutic agents for disorders that involve excessive membrane lipids peroxidation and HNE-mediated neuronal toxicity.

Original languageEnglish (US)
Pages (from-to)6156-6161
Number of pages6
JournalJournal of Medicinal Chemistry
Volume48
Issue number19
DOIs
StatePublished - Sep 22 2005
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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