Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

Yousef Ahmadibeni, Keykavous Parang

Research output: Contribution to journalArticlepeer-review

Abstract

Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)4739-4743
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number25
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • CD spectropolarimetry
  • Diphosphodiesters
  • Nucleotides
  • Solid-phase synthesis
  • Thermal analysis

ASJC Scopus subject areas

  • Chemistry(all)

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