Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Xiao Ming Zha, Fei Ran Zhang, Jia Qi Shan, Yi Hua Zhang, Jun O. Liu, Hong Bin Sun

Research output: Contribution to journalArticle

Abstract

Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=3.91μmol/L).

Original languageEnglish (US)
Pages (from-to)1087-1090
Number of pages4
JournalChinese Chemical Letters
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2010

Keywords

  • Derivatives
  • In vitro anticancer
  • Solasodine

ASJC Scopus subject areas

  • Chemistry(all)

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