Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Xiao Ming Zha; Fei Ran Zhang; Jia Qi Shan; Yi Hua Zhang; Jun O. Liu; Hong Bin Sun

doi:10.1016/j.cclet.2010.04.020

Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Xiao Ming Zha, Fei Ran Zhang, Jia Qi Shan, Yi Hua Zhang, Jun O. Liu, Hong Bin Sun

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC₅₀=3.91μmol/L).

Original language	English (US)
Pages (from-to)	1087-1090
Number of pages	4
Journal	Chinese Chemical Letters
Volume	21
Issue number	9
DOIs	https://doi.org/10.1016/j.cclet.2010.04.020
State	Published - Sep 2010

Keywords

Derivatives
In vitro anticancer
Solasodine

ASJC Scopus subject areas

General Chemistry

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10.1016/j.cclet.2010.04.020

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title = "Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives",

abstract = "Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=3.91μmol/L).",

keywords = "Derivatives, In vitro anticancer, Solasodine",

author = "Zha, {Xiao Ming} and Zhang, {Fei Ran} and Shan, {Jia Qi} and Zhang, {Yi Hua} and Liu, {Jun O.} and Sun, {Hong Bin}",

year = "2010",

month = sep,

doi = "10.1016/j.cclet.2010.04.020",

language = "English (US)",

volume = "21",

pages = "1087--1090",

journal = "Chinese Chemical Letters",

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T1 - Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

AU - Zha, Xiao Ming

AU - Zhang, Fei Ran

AU - Shan, Jia Qi

AU - Zhang, Yi Hua

AU - Liu, Jun O.

AU - Sun, Hong Bin

PY - 2010/9

Y1 - 2010/9

N2 - Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=3.91μmol/L).

AB - Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=3.91μmol/L).

KW - Derivatives

KW - In vitro anticancer

KW - Solasodine

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UR - http://www.scopus.com/inward/citedby.url?scp=77955050584&partnerID=8YFLogxK

U2 - 10.1016/j.cclet.2010.04.020

DO - 10.1016/j.cclet.2010.04.020

M3 - Article

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VL - 21

SP - 1087

EP - 1090

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 9

ER -

Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Abstract

Keywords

ASJC Scopus subject areas

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