Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors

A. Rafinejad, A. Fallah-Tafti, R. Tiwari, A. Nasrolahi Shirazi, D. Mandal, K. Parang, A. Foroumadi, T. Akbarzadeh

Research output: Contribution to journalArticle

Abstract

In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalJournal of Sciences, Islamic Republic of Iran
Volume26
Issue number4
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

src-Family Kinases
Derivatives
Staurosporine
Oxalates
Ethanol
Pharmaceutical Preparations
acetophenone
sodium ethoxide

Keywords

  • Cancer
  • Ethyl 2,4-dioxo-4-arylbutanoates
  • Src Kinase

ASJC Scopus subject areas

  • General

Cite this

Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Shirazi, A. N., Mandal, D., Parang, K., ... Akbarzadeh, T. (2015). Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors. Journal of Sciences, Islamic Republic of Iran, 26(4), 321-325.

Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors. / Rafinejad, A.; Fallah-Tafti, A.; Tiwari, R.; Shirazi, A. Nasrolahi; Mandal, D.; Parang, K.; Foroumadi, A.; Akbarzadeh, T.

In: Journal of Sciences, Islamic Republic of Iran, Vol. 26, No. 4, 01.09.2015, p. 321-325.

Research output: Contribution to journalArticle

Rafinejad, A, Fallah-Tafti, A, Tiwari, R, Shirazi, AN, Mandal, D, Parang, K, Foroumadi, A & Akbarzadeh, T 2015, 'Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors', Journal of Sciences, Islamic Republic of Iran, vol. 26, no. 4, pp. 321-325.
Rafinejad A, Fallah-Tafti A, Tiwari R, Shirazi AN, Mandal D, Parang K et al. Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors. Journal of Sciences, Islamic Republic of Iran. 2015 Sep 1;26(4):321-325.
Rafinejad, A. ; Fallah-Tafti, A. ; Tiwari, R. ; Shirazi, A. Nasrolahi ; Mandal, D. ; Parang, K. ; Foroumadi, A. ; Akbarzadeh, T. / Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors. In: Journal of Sciences, Islamic Republic of Iran. 2015 ; Vol. 26, No. 4. pp. 321-325.
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AU - Foroumadi, A.

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