Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

David C. Limburg, Bert E. Thomas IV, Jia He Li, Mike Fuller, Dawn Spicer, Yi Chen, Hongzhi Guo, Joseph P. Steiner, Gregory S. Hamilton, Yong Qian Wu

Research output: Contribution to journalArticle

Abstract

As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.

Original languageEnglish (US)
Pages (from-to)3867-3870
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number21
DOIs
StatePublished - Nov 3 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Limburg, D. C., Thomas IV, B. E., Li, J. H., Fuller, M., Spicer, D., Chen, Y., Guo, H., Steiner, J. P., Hamilton, G. S., & Wu, Y. Q. (2003). Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands. Bioorganic and Medicinal Chemistry Letters, 13(21), 3867-3870. https://doi.org/10.1016/S0960-894X(03)00758-3