TY - JOUR
T1 - Synthesis and evaluation of antiproliferative activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides
AU - Motavallizadeh, Somayeh
AU - Fallah-Tafti, Asal
AU - Maleki, Saeedeh
AU - Shirazi, Amir Nasrolahi
AU - Pordeli, Mahboobeh
AU - Safavi, Maliheh
AU - Ardestani, Sussan Kabudanian
AU - Asd, Shaaban
AU - Tiwari, Rakesh
AU - Oh, Donghoon
AU - Shafiee, Abbas
AU - Foroumadi, Alireza
AU - Parang, Keykavous
AU - Akbarzadeh, Tahmineh
PY - 2014/1/8
Y1 - 2014/1/8
N2 - Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines including breast cancer cell lines (MDA-MB-231, T-47D) and neuroblastoma cell line (SK-N-MC) using MTT colorimetric assay. Etoposide, a well-known anticancer drug, was used as a positive standard drug. Among synthesized compounds, 4-methoxy-N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide (5i) showed the highest antiproliferative activity against MDA-MB-231, T-47D, and SK-N-MC cells. Furthermore, pentafluoro derivatives 5a and 6a exhibited higher antiproliferative activity than doxorubicin against human leukemia cell line (CCRF-CEM) and breast adenocarcinoma (MDA-MB-468) cells. Structure-activity relationship studies revealed that xanthone benzenesulfonamide hybrid compounds can be used for the development of new lead anticancer agents.
AB - Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines including breast cancer cell lines (MDA-MB-231, T-47D) and neuroblastoma cell line (SK-N-MC) using MTT colorimetric assay. Etoposide, a well-known anticancer drug, was used as a positive standard drug. Among synthesized compounds, 4-methoxy-N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide (5i) showed the highest antiproliferative activity against MDA-MB-231, T-47D, and SK-N-MC cells. Furthermore, pentafluoro derivatives 5a and 6a exhibited higher antiproliferative activity than doxorubicin against human leukemia cell line (CCRF-CEM) and breast adenocarcinoma (MDA-MB-468) cells. Structure-activity relationship studies revealed that xanthone benzenesulfonamide hybrid compounds can be used for the development of new lead anticancer agents.
KW - Antiproliferative activity
KW - Benzenesulfonamides
KW - Cancer
KW - Xanthone
UR - http://www.scopus.com/inward/record.url?scp=84890803583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890803583&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2013.11.033
DO - 10.1016/j.tetlet.2013.11.033
M3 - Article
C2 - 24453382
AN - SCOPUS:84890803583
SN - 0040-4039
VL - 55
SP - 373
EP - 375
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 2
ER -