Synthesis and evaluation of airway targeted plga nanoparticles for drug delivery in obstructive lung diseases

Neeraj Vij

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic airway inflammation is a hallmark of chronic obstructive airway diseases, including asthma, COPD (chronic obstructive pulmonary disease), and CF (cystic fibrosis). It is also a major challenge in delivery and therapeutic efficacy of nano-based delivery systems in these chronic airway conditions as nanoparticle (NP) need to bypass airways defense mechanisms as we recently discussed. NPs which are capable of overcoming airways defense mechanisms should allow targeted drug delivery to disease cells. Over the last decade there has been increasing interest in development of targeted NPs for cancer but relatively little effort on designing novel systems for treating chronic inflammatory and obstructive airway conditions. Here we describe methods for preparing drug loaded multifunctional nanoparticles for targeted delivery to specific cell types in airways. The formulations and methods for selective drug delivery, discussed here are currently under preclinical development in our laboratory for treating chronic airway conditions such as COPD, CF, and asthma.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages303-310
Number of pages8
Volume906
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume906
ISSN (Print)10643745

Keywords

  • Asthma
  • CF
  • COPD
  • Inflammation and lung disease
  • PLGA nanoparticles
  • Therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Vij, N. (2012). Synthesis and evaluation of airway targeted plga nanoparticles for drug delivery in obstructive lung diseases. In Methods in Molecular Biology (Vol. 906, pp. 303-310). (Methods in Molecular Biology; Vol. 906). https://doi.org/10.1007/978-1-61779-953-2_24