Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate-caged SPP

Lixin Qiao, Alan P. Kozikowski, Ana Olivera, Sarah Spiegel

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of a photolyzable sphingosine 1-phosphate derivative is reported via the reaction of N-(tert-butoxycarbonyl)-2-N,3-O-isopropylidenesphingosine 7 and bis(α-methyl-o-nitrobenzyl) N,N-diisopropylphosphoramidite. Stimulation of DNA synthesis upon illumination of caged SPP-loaded cells is also described.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number7
DOIs
StatePublished - Apr 7 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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