Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro

Franco Chimenti, Bruna Bizzarri, Adriana Bolasco, Daniela Secci, Paola Chimenti, Simone Carradori, Arianna Granese, Daniela Rivanera, Nathan Frishberg, Claudia Bordón, Lorraine Jones-Brando

Research output: Contribution to journalArticlepeer-review

Abstract

A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.

Original languageEnglish (US)
Pages (from-to)4574-4577
Number of pages4
JournalJournal of medicinal chemistry
Volume52
Issue number15
DOIs
StatePublished - Aug 13 2009
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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