Synthesis and evaluation of 1-position-modified inositol 1,4,5- trisphosphate analogs

Takanari Inoue, Kazuya Kikuchi, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano

Research output: Contribution to journalArticle

Abstract

IP3 analogs were synthesized by the modification of phosphate at the 1- position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number12
DOIs
StatePublished - Jun 21 1999
Externally publishedYes

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Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Surface Plasmon Resonance
Surface plasmon resonance
Phosphates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and evaluation of 1-position-modified inositol 1,4,5- trisphosphate analogs. / Inoue, Takanari; Kikuchi, Kazuya; Hirose, Kenzo; Iino, Masamitsu; Nagano, Tetsuo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 12, 21.06.1999, p. 1697-1702.

Research output: Contribution to journalArticle

Inoue, Takanari ; Kikuchi, Kazuya ; Hirose, Kenzo ; Iino, Masamitsu ; Nagano, Tetsuo. / Synthesis and evaluation of 1-position-modified inositol 1,4,5- trisphosphate analogs. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 12. pp. 1697-1702.
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