Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives

Yakini Brandy, Nailah Brandy, Emmanuel Akinboye, Malik Lewis, Claudia Mouamba, Seshat MacK, Ray J. Butcher, Alan J. Anderson, Oladapo Bakare

Research output: Contribution to journalArticle

Abstract

Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.

Original languageEnglish (US)
Pages (from-to)1973-1984
Number of pages12
JournalMolecules
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

Fingerprint

sodium hydrides
acylation
halos
analogs
Derivatives
Acylation
synthesis
1,4-naphthoquinone

Keywords

  • 1,4-naphthoquinone
  • Imide synthesis
  • Sodium hydride-promoted bis-acylation
  • Unsymmetrical imide

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives. / Brandy, Yakini; Brandy, Nailah; Akinboye, Emmanuel; Lewis, Malik; Mouamba, Claudia; MacK, Seshat; Butcher, Ray J.; Anderson, Alan J.; Bakare, Oladapo.

In: Molecules, Vol. 18, No. 2, 01.02.2013, p. 1973-1984.

Research output: Contribution to journalArticle

Brandy, Yakini ; Brandy, Nailah ; Akinboye, Emmanuel ; Lewis, Malik ; Mouamba, Claudia ; MacK, Seshat ; Butcher, Ray J. ; Anderson, Alan J. ; Bakare, Oladapo. / Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives. In: Molecules. 2013 ; Vol. 18, No. 2. pp. 1973-1984.
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