Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives

Yakini Brandy, Nailah Brandy, Emmanuel Akinboye, Malik Lewis, Claudia Mouamba, Seshat MacK, Ray J. Butcher, Alan J. Anderson, Oladapo Bakare

Research output: Contribution to journalArticlepeer-review

Abstract

Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.

Original languageEnglish (US)
Pages (from-to)1973-1984
Number of pages12
JournalMolecules
Volume18
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • 1,4-naphthoquinone
  • Imide synthesis
  • Sodium hydride-promoted bis-acylation
  • Unsymmetrical imide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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