Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging

Cong Li; Tiffany R. Greenwood; Zaver M. Bhujwalla; Kristine Glunde

doi:10.1021/ol060783e

Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging

Cong Li, Tiffany R. Greenwood, Zaver M. Bhujwalla, Kristine Glunde

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

Original language	English (US)
Pages (from-to)	3623-3626
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	17
DOIs	https://doi.org/10.1021/ol060783e
State	Published - Aug 17 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol060783e

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abstract = "Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.",

author = "Cong Li and Greenwood, {Tiffany R.} and Bhujwalla, {Zaver M.} and Kristine Glunde",

year = "2006",

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Y1 - 2006/8/17

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AB - Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

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Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging

Abstract

ASJC Scopus subject areas

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