Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging

Cong Li, Tiffany R. Greenwood, Zaver M. Bhujwalla, Kristine Glunde

Research output: Contribution to journalArticlepeer-review

Abstract

Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

Original languageEnglish (US)
Pages (from-to)3623-3626
Number of pages4
JournalOrganic Letters
Volume8
Issue number17
DOIs
StatePublished - Aug 17 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging'. Together they form a unique fingerprint.

Cite this