Synthesis and biological evaluation of (±)-Z-huperzine A

Alan P. Kozikowski, Fumio Yamada, X. C. Tang, Israel Hanin

Research output: Contribution to journalArticle


The synthesis of (±)-Z-huperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. The compound has an IC50 of 6 x 10-6 M, which is comparable to that of huperzine B.

Original languageEnglish (US)
Pages (from-to)6159-6162
Number of pages4
JournalTetrahedron Letters
Issue number43
Publication statusPublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Kozikowski, A. P., Yamada, F., Tang, X. C., & Hanin, I. (1990). Synthesis and biological evaluation of (±)-Z-huperzine A. Tetrahedron Letters, 31(43), 6159-6162.