Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping; John Babich; Jon A. Zubieta; Kenneth M. Johnson; Susanne Machill; Alan P. Kozikowski

doi:10.1016/S0960-894X(99)00562-4

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping, John Babich, Jon A. Zubieta, Kenneth M. Johnson, Susanne Machill, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

Original language	English (US)
Pages (from-to)	3211-3216
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(99)00562-4
State	Published - Nov 15 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(99)00562-4

Cite this

@article{4f20658958994c7e8318bf083e4434dc,

title = "Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine",

abstract = "Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.",

author = "Alexander Hoepping and John Babich and Zubieta, {Jon A.} and Johnson, {Kenneth M.} and Susanne Machill and Kozikowski, {Alan P.}",

year = "1999",

month = nov,

day = "15",

doi = "10.1016/S0960-894X(99)00562-4",

language = "English (US)",

volume = "9",

pages = "3211--3216",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "22",

}

TY - JOUR

T1 - Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

AU - Hoepping, Alexander

AU - Babich, John

AU - Zubieta, Jon A.

AU - Johnson, Kenneth M.

AU - Machill, Susanne

AU - Kozikowski, Alan P.

PY - 1999/11/15

Y1 - 1999/11/15

N2 - Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

AB - Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

UR - http://www.scopus.com/inward/record.url?scp=0033571663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033571663&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(99)00562-4

DO - 10.1016/S0960-894X(99)00562-4

M3 - Article

C2 - 10576690

AN - SCOPUS:0033571663

SN - 0960-894X

VL - 9

SP - 3211

EP - 3216

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this