Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Alexander Hoepping, John Babich, Jon A. Zubieta, Kenneth M. Johnson, Susanne Machill, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

Two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithiol (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake.

Original languageEnglish (US)
Pages (from-to)3211-3216
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number22
StatePublished - Nov 15 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Hoepping, A., Babich, J., Zubieta, J. A., Johnson, K. M., Machill, S., & Kozikowski, A. P. (1999). Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. Bioorganic and Medicinal Chemistry Letters, 9(22), 3211-3216.