Synthesis and Biological Activity of D‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents

Alan P. Kozikowski; Werner Tückmantel; Garth Powis

doi:10.1002/anie.199213791

Synthesis and Biological Activity of D‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents

Alan P. Kozikowski, Werner Tückmantel, Garth Powis

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

myo‐Inositol causes no disruption in the growth‐inhibiting effect of the phos‐phatidylinositol (Ptdlns) derivative 1. This first synthetic Ptdlns analogue with a myo‐inositol configuration may point the way to new anti‐cancer agents based on the interruption of Pdtlns signaling, which do not inhibit cell growth by interaction with DNA. (Figure Presented.)

Original language	English (US)
Pages (from-to)	1379-1381
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	31
Issue number	10
DOIs	https://doi.org/10.1002/anie.199213791
State	Published - Oct 1992
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry

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Synthesis and Biological Activity of D‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents. / Kozikowski, Alan P.; Tückmantel, Werner; Powis, Garth.
In: Angewandte Chemie International Edition in English, Vol. 31, No. 10, 10.1992, p. 1379-1381.

Research output: Contribution to journal › Article › peer-review

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Synthesis and Biological Activity of D‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents

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