Synthesis and Biological Activity of D‐3‐Deoxy‐3‐Fluorophosphatidylinositol—A New Direction in the Design of non‐DNA Targeted Anticancer Agents

Alan P. Kozikowski, Werner Tückmantel, Garth Powis

Research output: Contribution to journalArticlepeer-review

Abstract

myo‐Inositol causes no disruption in the growth‐inhibiting effect of the phos‐phatidylinositol (Ptdlns) derivative 1. This first synthetic Ptdlns analogue with a myo‐inositol configuration may point the way to new anti‐cancer agents based on the interruption of Pdtlns signaling, which do not inhibit cell growth by interaction with DNA. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume31
Issue number10
DOIs
StatePublished - Oct 1992
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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