Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists

Dawei Ma, Hongqi Tian, Hongbin Sun, Alan P. Kozikowski, Sergey Pshenichkin, Jarda T. Wroblewski

Research output: Contribution to journalArticle

Abstract

The synthesis of two rigidified phenylglycine analogues is disclosed. The cyclic analogue 1 of (R,S)-α-methyl-4-phosphonophenylglycine (MPPG) is shown to be a particularly interesting pharmacological tool, for it is a group II selective mGluR antagonist that possesses an inverse agonist-like action.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number9
DOIs
StatePublished - May 6 1997
Externally publishedYes

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Excitatory Amino Acid Antagonists
Metabotropic Glutamate Receptors
Bioactivity
Pharmacology
4-phosphonophenylglycine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. / Ma, Dawei; Tian, Hongqi; Sun, Hongbin; Kozikowski, Alan P.; Pshenichkin, Sergey; Wroblewski, Jarda T.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 9, 06.05.1997, p. 1195-1198.

Research output: Contribution to journalArticle

Ma, Dawei ; Tian, Hongqi ; Sun, Hongbin ; Kozikowski, Alan P. ; Pshenichkin, Sergey ; Wroblewski, Jarda T. / Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 9. pp. 1195-1198.
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