Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists

Dawei Ma, Hongqi Tian, Hongbin Sun, Alan P. Kozikowski, Sergey Pshenichkin, Jarda T. Wroblewski

Research output: Contribution to journalArticle

Abstract

The synthesis of two rigidified phenylglycine analogues is disclosed. The cyclic analogue 1 of (R,S)-α-methyl-4-phosphonophenylglycine (MPPG) is shown to be a particularly interesting pharmacological tool, for it is a group II selective mGluR antagonist that possesses an inverse agonist-like action.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number9
DOIs
StatePublished - May 6 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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