Synthesis and biological activity of an optically pure 10-spirocyclopropyl analog of huperzine A

Alan P. Kozikowski, K. R.C. Prakash, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journalArticle

Abstract

The synthesis of a spirocyclic analog of huperzine A that bears a cyclopropane ring at its 10-position has been carried out in an enantioselective manner using a diastereoselective Michael-aldol reaction; in assays of AChE inhibition, this compound was found to be nearly as active as huperzine A itself, with comparable on and off rates from the enzyme.

Original languageEnglish (US)
Pages (from-to)1287-1288
Number of pages2
JournalChemical Communications
Issue number12
DOIs
StatePublished - Jun 21 1998

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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