Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

Haiying Sun, Gaddam Bapu Reddy, Clifford George, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

Original languageEnglish (US)
Pages (from-to)2835-2838
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number15
DOIs
StatePublished - Apr 8 2002

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Sun, H., Bapu Reddy, G., George, C., Meuillet, E. J., Berggren, M., Powis, G., & Kozikowski, A. P. (2002). Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues. Tetrahedron Letters, 43(15), 2835-2838. https://doi.org/10.1016/S0040-4039(02)00354-4