Synthesis and antitumor evaluation of benzoylphenylurea analogs

Hallur Gurulingappa, Maria L. Amador, Ming Zhao, Michelle A. Rudek, Manuel Hidalgo, Saeed R. Khan

Research output: Contribution to journalArticle

Abstract

Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number9
DOIs
StatePublished - May 3 2004

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Keywords

  • Antitumor agents
  • Benzoylphenylurea analogs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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