Synthesis and antitumor evaluation of benzoylphenylurea analogs

Hallur Gurulingappa; Maria L. Amador; Ming Zhao; Michelle A. Rudek; Manuel Hidalgo; Saeed R. Khan

doi:10.1016/j.bmcl.2004.02.019

Synthesis and antitumor evaluation of benzoylphenylurea analogs

Hallur Gurulingappa, Maria L. Amador, Ming Zhao, Michelle A. Rudek, Manuel Hidalgo, Saeed R. Khan

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.

Original language	English (US)
Pages (from-to)	2213-2216
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.019
State	Published - May 3 2004

Keywords

Antitumor agents
Benzoylphenylurea analogs

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.02.019

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title = "Synthesis and antitumor evaluation of benzoylphenylurea analogs",

abstract = "Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.",

keywords = "Antitumor agents, Benzoylphenylurea analogs",

author = "Hallur Gurulingappa and Amador, {Maria L.} and Ming Zhao and Rudek, {Michelle A.} and Manuel Hidalgo and Khan, {Saeed R.}",

note = "Funding Information: We thank Sharyn Baker and Yelena Zabelina for helpful discussions. Supported by grant from Commonwealth Foundation for Cancer Research to M.A.R. and M.H., and an intramural grant from the Maryland Cigarette Restitution Fund to S.R.K.",

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doi = "10.1016/j.bmcl.2004.02.019",

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T1 - Synthesis and antitumor evaluation of benzoylphenylurea analogs

AU - Gurulingappa, Hallur

AU - Amador, Maria L.

AU - Zhao, Ming

AU - Rudek, Michelle A.

AU - Hidalgo, Manuel

AU - Khan, Saeed R.

N1 - Funding Information: We thank Sharyn Baker and Yelena Zabelina for helpful discussions. Supported by grant from Commonwealth Foundation for Cancer Research to M.A.R. and M.H., and an intramural grant from the Maryland Cigarette Restitution Fund to S.R.K.

PY - 2004/5/3

Y1 - 2004/5/3

N2 - Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.

AB - Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7.

KW - Antitumor agents

KW - Benzoylphenylurea analogs

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JO - Bioorganic and Medicinal Chemistry Letters

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Synthesis and antitumor evaluation of benzoylphenylurea analogs

Abstract

Keywords

ASJC Scopus subject areas

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