Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues

You Wang, Feiran Zhang, Yihua Zhang, Jun O. Liu, Dawei Ma

Research output: Contribution to journalArticle

Abstract

The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)4385-4387
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number15
DOIs
StatePublished - Aug 1 2008

Keywords

  • Anti-tumor
  • Cyclopeptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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