Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs

Bryan T. Mott, Abhai Tripathi, Maxime A. Siegler, Cathy D. Moore, David J Sullivan, Gary H. Posner

Research output: Contribution to journalArticle

Abstract

Malaria continues to be a difficult disease to eradicate largely because of the widespread populations it affects and the resistance that malaria parasites have developed against once very potent therapies. The natural product artemisinin has been a boon for antimalarial chemotherapy, as artemisinin combination therapy (ACT) has become the first line of chemotherapy. Because the threat of resistance is always on the horizon, it is imperative to continually identify new treatments, comprising both advanced analogues of all antimalarial drugs, especially artemisinin, and the exploration of novel combinations, ideally with distinct mechanisms of action. Here we report for the first time the synthesis of a series of two-carbon-linked artemisinin-derived dimers, their unique structural features, and demonstration of their antimalarial efficacy via single oral dose administration in two 60-day survival studies of Plasmodium berghei infected mice. Several of the new endoperoxide chemical entities consistently demonstrated excellent antimalarial efficacy, and combinations with two non-peroxide antimalarial drugs have been studied.

Original languageEnglish (US)
Pages (from-to)2630-2641
Number of pages12
JournalJournal of Medicinal Chemistry
Volume56
Issue number6
DOIs
StatePublished - Mar 28 2013

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Antimalarials
Carbon
Malaria
Plasmodium berghei
Drug Therapy
Biological Products
Oral Administration
Parasites
Therapeutics
artemisinine
Population

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs. / Mott, Bryan T.; Tripathi, Abhai; Siegler, Maxime A.; Moore, Cathy D.; Sullivan, David J; Posner, Gary H.

In: Journal of Medicinal Chemistry, Vol. 56, No. 6, 28.03.2013, p. 2630-2641.

Research output: Contribution to journalArticle

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