Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy

Cordula Grüttner, Knut Müller, Joachim Teller, Fritz Westphal, Allan Foreman, Robert Ivkov

Research output: Contribution to journalArticlepeer-review

Abstract

Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immunoreactivity of the final antibody-particle conjugate.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume311
Issue number1 SPEC. ISS.
DOIs
StatePublished - Apr 2007
Externally publishedYes

Keywords

  • Alternating magnetic field
  • Antibody conjugation
  • Cancer therapy
  • Hyperthermia
  • Magnetic nanoparticle
  • Specific power absorption rate

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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