Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

James McNulty, Ramesh Vemula, Claudia Bordón, Robert Yolken, Lorraine Jones-Brando

Research output: Contribution to journalArticlepeer-review

Abstract

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number2
DOIs
StatePublished - Jan 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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