Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

James McNulty; Ramesh Vemula; Claudia Bordón; Robert Yolken; Lorraine Jones-Brando

doi:10.1039/c3ob41539b

Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

James McNulty, Ramesh Vemula, Claudia Bordón, Robert Yolken, Lorraine Jones-Brando

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.

Original language	English (US)
Pages (from-to)	255-260
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	2
DOIs	https://doi.org/10.1039/c3ob41539b
State	Published - Jan 14 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.",

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Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

Abstract

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